Title |
Immunocytochemical analysis of P2X2 in rat circumvallate taste buds
|
---|---|
Published in |
BMC Neuroscience, May 2012
|
DOI | 10.1186/1471-2202-13-51 |
Pubmed ID | |
Authors |
Ruibiao Yang, Alana Montoya, Amanda Bond, Jenna Walton, John C Kinnamon |
Abstract |
Our laboratory has shown that classical synapses and synaptic proteins are associated with Type III cells. Yet it is generally accepted that Type II cells transduce bitter, sweet and umami stimuli. No classical synapses, however, have been found associated with Type II cells. Recent studies indicate that the ionotropic purinergic receptors P2X2/P2X3 are present in rodent taste buds. Taste nerve processes express the ionotropic purinergic receptors (P2X2/P2X3). P2X2/P2X3(Dbl-/-) mice are not responsive to sweet, umami and bitter stimuli, and it has been proposed that ATP acts as a neurotransmitter in taste buds. The goal of the present study is to learn more about the nature of purinergic contacts in rat circumvallate taste buds by examining immunoreactivity to antisera directed against the purinergic receptor P2X2. |
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