Title |
Effects of indole on drug resistance and virulence of Salmonella enterica serovar Typhimurium revealed by genome-wide analyses
|
---|---|
Published in |
Gut Pathogens, May 2012
|
DOI | 10.1186/1757-4749-4-5 |
Pubmed ID | |
Authors |
Eiji Nikaido, Etienne Giraud, Sylvie Baucheron, Suguru Yamasaki, Agnès Wiedemann, Kousuke Okamoto, Tatsuya Takagi, Akihito Yamaguchi, Axel Cloeckaert, Kunihiko Nishino |
Abstract |
Many Gram-positive and Gram-negative bacteria produce large quantities of indole as an intercellular signal in microbial communities. Indole demonstrated to affect gene expression in Escherichia coli as an intra-species signaling molecule. In contrast to E. coli, Salmonella does not produce indole because it does not harbor tnaA, which encodes the enzyme responsible for tryptophan metabolism. Our previous study demonstrated that E. coli-conditioned medium and indole induce expression of the AcrAB multidrug efflux pump in Salmonella enterica serovar Typhimurium for inter-species communication; however, the global effect of indole on genes in Salmonella remains unknown. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 33% |
Canada | 1 | 17% |
Cameroon | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 3 | 50% |
Members of the public | 3 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 2% |
United States | 1 | <1% |
Greece | 1 | <1% |
South Africa | 1 | <1% |
Unknown | 118 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 32 | 26% |
Student > Bachelor | 17 | 14% |
Researcher | 12 | 10% |
Student > Master | 12 | 10% |
Student > Postgraduate | 8 | 7% |
Other | 16 | 13% |
Unknown | 26 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 42 | 34% |
Biochemistry, Genetics and Molecular Biology | 17 | 14% |
Immunology and Microbiology | 7 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
Chemistry | 5 | 4% |
Other | 17 | 14% |
Unknown | 29 | 24% |