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An adaptive association test for microbiome data

Overview of attention for article published in Genome Medicine, May 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

blogs
1 blog
twitter
21 X users
googleplus
1 Google+ user

Citations

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73 Dimensions

Readers on

mendeley
93 Mendeley
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Title
An adaptive association test for microbiome data
Published in
Genome Medicine, May 2016
DOI 10.1186/s13073-016-0302-3
Pubmed ID
Authors

Chong Wu, Jun Chen, Junghi Kim, Wei Pan

Abstract

There is increasing interest in investigating how the compositions of microbial communities are associated with human health and disease. Although existing methods have identified many associations, a proper choice of a phylogenetic distance is critical for the power of these methods. To assess an overall association between the composition of a microbial community and an outcome of interest, we present a novel multivariate testing method called aMiSPU, that is joint and highly adaptive over all observed taxa and thus high powered across various scenarios, alleviating the issue with the choice of a phylogenetic distance. Our simulations and real-data analyses demonstrated that the aMiSPU test was often more powerful than several competing methods while correctly controlling type I error rates. The R package MiSPU is available at https://github.com/ChongWu-Biostat/MiSPU and CRAN.

X Demographics

X Demographics

The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 3%
Germany 1 1%
India 1 1%
Brazil 1 1%
Japan 1 1%
Canada 1 1%
Unknown 85 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 27%
Researcher 19 20%
Student > Master 13 14%
Other 6 6%
Student > Doctoral Student 6 6%
Other 14 15%
Unknown 10 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 27%
Biochemistry, Genetics and Molecular Biology 15 16%
Computer Science 12 13%
Mathematics 9 10%
Medicine and Dentistry 6 6%
Other 12 13%
Unknown 14 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2016.
All research outputs
#1,910,856
of 24,885,505 outputs
Outputs from Genome Medicine
#430
of 1,532 outputs
Outputs of similar age
#33,287
of 341,126 outputs
Outputs of similar age from Genome Medicine
#18
of 33 outputs
Altmetric has tracked 24,885,505 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,532 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.2. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,126 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.