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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Reduced task-related functional connectivity during a set-shifting task in unmedicated early-stage Parkinson’s disease patients
|
|---|---|
| Published in |
BMC Neuroscience, May 2016
|
| DOI | 10.1186/s12868-016-0254-y |
| Pubmed ID | |
| Authors |
Corine C. de Bondt, Niels J. H. M. Gerrits, Dick J. Veltman, Henk W. Berendse, Odile A. van den Heuvel, Ysbrand D. van der Werf |
| Abstract |
Patients with Parkinson's disease (PD) often suffer from cognitive impairments, including set-shifting deficits, in addition to the characteristic motor symptoms. It is hypothesized that the striatal dopamine depletion leads to a sub-optimal functional connectivity between task-related brain areas and consequently results in impaired task-performance. In this study, we aimed to examine this hypothesis by investigating the task-related functional connectivity of brain areas that are believed to be involved in set-shifting, such as the dorsolateral prefrontal cortex (DLPFC), posterior parietal cortex (PPC) and the superior frontal gyrus (SFG), during a set-shifting task. We obtained functional imaging data from 18 early-stage PD patients and 35 healthy controls, matched at the group level, using a newly developed rule-based set-shifting task that required participants to manually respond to arrow stimuli based on their location on the screen of their direction. We found that early stage PD patients, compared with controls, showed (1) a decrease in positive coupling between the left DLPFC and the right insular cortex, and the right SFG and anterior cingulate cortex, (2) an increase in negative coupling between the right SFG and the anterior cingulate cortex, primary motor cortex, precuneus, and PPC, and (3) an increase in negative coupling between the left DLPFC and the left and right SFG. These results indicate that important task-related areas of PD patients have decreased functional connectivity with task-related regions and increased connectivity with task-unrelated areas. The disruption of functional connectivity in early stage PD patients during set-shifting reported here is likely compensated for by the local hyperactivation we reported earlier, thereby forestalling behavioural deficits. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 56 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 14% |
| Student > Ph. D. Student | 7 | 13% |
| Student > Bachelor | 6 | 11% |
| Student > Master | 6 | 11% |
| Student > Doctoral Student | 4 | 7% |
| Other | 7 | 13% |
| Unknown | 18 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 12 | 21% |
| Medicine and Dentistry | 9 | 16% |
| Neuroscience | 7 | 13% |
| Nursing and Health Professions | 2 | 4% |
| Sports and Recreations | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 19 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 May 2016.
All research outputs
#3,207,500
of 22,870,727 outputs
Outputs from BMC Neuroscience
#134
of 1,246 outputs
Outputs of similar age
#58,319
of 334,246 outputs
Outputs of similar age from BMC Neuroscience
#3
of 30 outputs
Altmetric has tracked 22,870,727 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,246 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,246 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.