Title |
Wnt-reporter expression pattern in the mouse intestine during homeostasis
|
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Published in |
BMC Gastroenterology, December 2008
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DOI | 10.1186/1471-230x-8-57 |
Pubmed ID | |
Authors |
Paige S Davies, Adria D Dismuke, Anne E Powell, Kevin H Carroll, Melissa H Wong |
Abstract |
The canonical Wnt signaling pathway is a known regulator of cell proliferation during development and maintenance of the intestinal epithelium. Perturbations in this pathway lead to aberrant epithelial proliferation and intestinal cancer. In the mature intestine, proliferation is confined to the relatively quiescent stem cells and the rapidly cycling transient-amplifying cells in the intestinal crypts. Although the Wnt signal is believed to regulate all proliferating intestinal cells, surprisingly, this has not been thoroughly demonstrated. This important determination has implications on intestinal function, especially during epithelial expansion and regeneration, and warrants an extensive characterization of Wnt-activated cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Italy | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 3 | 4% |
Mexico | 1 | 1% |
France | 1 | 1% |
Unknown | 79 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 22 | 26% |
Student > Ph. D. Student | 16 | 19% |
Student > Bachelor | 9 | 11% |
Student > Master | 7 | 8% |
Professor > Associate Professor | 4 | 5% |
Other | 11 | 13% |
Unknown | 15 | 18% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 29 | 35% |
Biochemistry, Genetics and Molecular Biology | 18 | 21% |
Medicine and Dentistry | 9 | 11% |
Immunology and Microbiology | 5 | 6% |
Computer Science | 2 | 2% |
Other | 5 | 6% |
Unknown | 16 | 19% |