Hi-C is used to link psychiatric and medical comorbidities. Read how Espeso-G et al. use #spatialgenomics to explore genomic architecture in midbrain dopaminergic neurons: https://t.co/o8q2fxf7AQ #HiC #schizophrenia
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We often think the genome as a linear string of DNA. But did you know that chromatin architecture might potentially confer susceptibility for particular disorders? Check our recent publication in Genome Medicine! https://t.co/XzJKG3UMEA
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A chromosomal connectome of Midbrain dopaminergic neurons (MDN): Hi-C helps identify 11 “Euclidean hot spots” of clustered chromatin domains harboring risk sequences for SCZ and elevated BMI. https://t.co/mXVVRvnG9g https://t.co/gCK5sDw4Es
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A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons. https://t.co/04crmfR9H8