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Conserved residue clusters at protein-protein interfaces and their use in binding site identification

Overview of attention for article published in BMC Bioinformatics, May 2010
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Title
Conserved residue clusters at protein-protein interfaces and their use in binding site identification
Published in
BMC Bioinformatics, May 2010
DOI 10.1186/1471-2105-11-286
Pubmed ID
Authors

Mainak Guharoy, Pinak Chakrabarti

Abstract

Biological evolution conserves protein residues that are important for structure and function. Both protein stability and function often require a certain degree of structural co-operativity between spatially neighboring residues and it has previously been shown that conserved residues occur clustered together in protein tertiary structures, enzyme active sites and protein-DNA interfaces. Residues comprising protein interfaces are often more conserved compared to those occurring elsewhere on the protein surface. We investigate the extent to which conserved residues within protein-protein interfaces are clustered together in three-dimensions.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 4 3%
United States 2 2%
Australia 1 <1%
Brazil 1 <1%
Israel 1 <1%
Germany 1 <1%
Canada 1 <1%
South Africa 1 <1%
Unknown 107 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 37 31%
Researcher 21 18%
Student > Master 18 15%
Student > Bachelor 10 8%
Professor > Associate Professor 7 6%
Other 12 10%
Unknown 14 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 49 41%
Biochemistry, Genetics and Molecular Biology 24 20%
Computer Science 8 7%
Chemistry 7 6%
Engineering 4 3%
Other 12 10%
Unknown 15 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2012.
All research outputs
#18,306,425
of 22,665,794 outputs
Outputs from BMC Bioinformatics
#6,285
of 7,247 outputs
Outputs of similar age
#86,132
of 95,741 outputs
Outputs of similar age from BMC Bioinformatics
#61
of 71 outputs
Altmetric has tracked 22,665,794 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,247 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
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We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.