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NF-κB2 mutation targets survival, proliferation and differentiation pathways in the pathogenesis of plasma cell tumors

Overview of attention for article published in BMC Cancer, May 2012
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1 tweeter

Citations

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4 Dimensions

Readers on

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26 Mendeley
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Title
NF-κB2 mutation targets survival, proliferation and differentiation pathways in the pathogenesis of plasma cell tumors
Published in
BMC Cancer, May 2012
DOI 10.1186/1471-2407-12-203
Pubmed ID
Authors

Brian A McCarthy, Liqun Yang, Jane Ding, Mingqiang Ren, William King, Mohammed ElSalanty, Ibrahim Zakhary, Mohamed Sharawy, Hongjuan Cui, Han-Fei Ding

Abstract

Abnormal NF-κB2 activation has been implicated in the pathogenesis of multiple myeloma, a cancer of plasma cells. However, a causal role for aberrant NF-κB2 signaling in the development of plasma cell tumors has not been established. Also unclear is the molecular mechanism that drives the tumorigenic process. We investigated these questions by using a transgenic mouse model with lymphocyte-targeted expression of p80HT, a lymphoma-associated NF-κB2 mutant, and human multiple myeloma cell lines.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 4%
Germany 1 4%
Unknown 24 92%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 19%
Student > Ph. D. Student 5 19%
Other 3 12%
Student > Master 3 12%
Researcher 3 12%
Other 3 12%
Unknown 4 15%
Readers by discipline Count As %
Medicine and Dentistry 9 35%
Agricultural and Biological Sciences 8 31%
Biochemistry, Genetics and Molecular Biology 3 12%
Immunology and Microbiology 2 8%
Unknown 4 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2012.
All research outputs
#2,898,625
of 3,631,167 outputs
Outputs from BMC Cancer
#1,372
of 1,786 outputs
Outputs of similar age
#52,793
of 72,744 outputs
Outputs of similar age from BMC Cancer
#43
of 69 outputs
Altmetric has tracked 3,631,167 research outputs across all sources so far. This one is in the 2nd percentile – i.e., 2% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,786 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 72,744 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.