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Mendeley readers
| Title |
Peripheral blood lymphocytes from low-grade squamous intraepithelial lesions patients recognize vaccine antigens in the presence of activated dendritic cells, and produced high levels of CD8 + IFNγ + T cells and low levels of IL-2 when induced to proliferate
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|---|---|
| Published in |
Infectious Agents and Cancer, May 2012
|
| DOI | 10.1186/1750-9378-7-12 |
| Pubmed ID | |
| Authors |
Jorge Hernández-Montes, Leticia Rocha-Zavaleta, Alberto Monroy-García, Benny Weiss-Steider, María del Carmen Zaragoza-Ortega, Fernando Cruz-Talonia, Omar Cruz y Cruz, Laura Bonifaz-Alfonso, Adriana Karina Chávez-Rueda, Martha Patricia Rojo-Aguilar, María Victoria Legorreta-Haquet, María de Lourdes Mora-García |
| Abstract |
Most infections with human papillomavirus (HPV) are resolved without clinical intervention, but a minority evolves into chronic lesions of distinct grades, including cervical-uterine cancer. It is known that in most cases the immune system mediates elimination of HPV infection. However, the mechanism of immune evasion leading to HPV persistence and development of early cervical lesions is not fully understood. The aim of the present work was to evaluate the potential of peripheral blood leukocytes (PBL) from low-grade squamous intraepithelial lesions (LSIL) patients to be activated ex-vivo by vaccine antigens, the participation of cytotoxic lymphocytes and regulatory T cells, and to determine the secretion of Th1 and Th2 cytokines mediated by stimulation of T cell receptors. |
Mendeley readers
The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 4% |
| Unknown | 24 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 20% |
| Student > Master | 5 | 20% |
| Researcher | 4 | 16% |
| Student > Bachelor | 2 | 8% |
| Other | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 7 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 32% |
| Medicine and Dentistry | 4 | 16% |
| Biochemistry, Genetics and Molecular Biology | 3 | 12% |
| Immunology and Microbiology | 2 | 8% |
| Social Sciences | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 6 | 24% |