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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Leaky ryanodine receptors in β-sarcoglycan deficient mice: a potential common defect in muscular dystrophy
|
|---|---|
| Published in |
Skeletal Muscle, May 2012
|
| DOI | 10.1186/2044-5040-2-9 |
| Pubmed ID | |
| Authors |
Daniel C Andersson, Albano C Meli, Steven Reiken, Matthew J Betzenhauser, Alisa Umanskaya, Takayuki Shiomi, Jeanine D’Armiento, Andrew R Marks |
| Abstract |
Disruption of the sarcolemma-associated dystrophin-glycoprotein complex underlies multiple forms of muscular dystrophy, including Duchenne muscular dystrophy and sarcoglycanopathies. A hallmark of these disorders is muscle weakness. In a murine model of Duchenne muscular dystrophy, mdx mice, cysteine-nitrosylation of the calcium release channel/ryanodine receptor type 1 (RyR1) on the skeletal muscle sarcoplasmic reticulum causes depletion of the stabilizing subunit calstabin1 (FKBP12) from the RyR1 macromolecular complex. This results in a sarcoplasmic reticular calcium leak via defective RyR1 channels. This pathological intracellular calcium leak contributes to reduced calcium release and decreased muscle force production. It is unknown whether RyR1 dysfunction occurs also in other muscular dystrophies. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Germany | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 55 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 28% |
| Student > Master | 9 | 16% |
| Researcher | 9 | 16% |
| Student > Bachelor | 6 | 10% |
| Professor | 5 | 9% |
| Other | 4 | 7% |
| Unknown | 9 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 33% |
| Biochemistry, Genetics and Molecular Biology | 13 | 22% |
| Medicine and Dentistry | 7 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Nursing and Health Professions | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 14 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 May 2013.
All research outputs
#14,726,101
of 22,665,794 outputs
Outputs from Skeletal Muscle
#309
of 360 outputs
Outputs of similar age
#101,567
of 165,043 outputs
Outputs of similar age from Skeletal Muscle
#5
of 7 outputs
Altmetric has tracked 22,665,794 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 360 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 165,043 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.