Title |
Functional region prediction with a set of appropriate homologous sequences-an index for sequence selection by integrating structure and sequence information with spatial statistics
|
---|---|
Published in |
BMC Molecular and Cell Biology, May 2012
|
DOI | 10.1186/1472-6807-12-11 |
Pubmed ID | |
Authors |
Wataru Nemoto, Hiroyuki Toh |
Abstract |
The detection of conserved residue clusters on a protein structure is one of the effective strategies for the prediction of functional protein regions. Various methods, such as Evolutionary Trace, have been developed based on this strategy. In such approaches, the conserved residues are identified through comparisons of homologous amino acid sequences. Therefore, the selection of homologous sequences is a critical step. It is empirically known that a certain degree of sequence divergence in the set of homologous sequences is required for the identification of conserved residues. However, the development of a method to select homologous sequences appropriate for the identification of conserved residues has not been sufficiently addressed. An objective and general method to select appropriate homologous sequences is desired for the efficient prediction of functional regions. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 3 | 50% |
United Kingdom | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 3 | 19% |
Student > Bachelor | 3 | 19% |
Student > Ph. D. Student | 2 | 13% |
Student > Master | 2 | 13% |
Student > Doctoral Student | 1 | 6% |
Other | 4 | 25% |
Unknown | 1 | 6% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 38% |
Agricultural and Biological Sciences | 6 | 38% |
Computer Science | 1 | 6% |
Engineering | 1 | 6% |
Unknown | 2 | 13% |