Title |
Why do antioxidants fail to provide clinical benefit?
|
---|---|
Published in |
Trials, August 2000
|
DOI | 10.1186/cvm-1-1-038 |
Pubmed ID | |
Authors |
Ascan Warnholtz, Thomas Münzel |
Abstract |
The results of recent randomized trials to test the influence of antioxidants on coronary-event rates and prognosis in patients with coronary-artery disease were disappointing. In none of these studies did the use of vitamin E improve prognosis. In contrast, treatment of coronary-artery disease with angiotensin-converting-enzyme (ACE) inhibitors reduced coronary-event rates and improved prognosis. ACE inhibition prevents the formation of angiotensin II, which has been shown to be a potent stimulus of superoxide-producing enzymes in atherosclerosis. The findings suggest that inhibition of superoxide production at enzymatic levels, rather than symptomatic superoxide scavenging, may be the better choice of treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 24% |
Student > Ph. D. Student | 2 | 12% |
Researcher | 2 | 12% |
Professor | 2 | 12% |
Student > Master | 2 | 12% |
Other | 2 | 12% |
Unknown | 3 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 41% |
Biochemistry, Genetics and Molecular Biology | 3 | 18% |
Agricultural and Biological Sciences | 2 | 12% |
Social Sciences | 1 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Other | 0 | 0% |
Unknown | 3 | 18% |