Title |
Effect of L-arginine supplement on liver regeneration after partial hepatectomy in rats
|
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Published in |
World Journal of Surgical Oncology, May 2012
|
DOI | 10.1186/1477-7819-10-99 |
Pubmed ID | |
Authors |
Tsuyoshi Kurokawa, Jun An, Koji Tsunekawa, Yoshiharu Shimomura, Shunsuke Kazama, Naohisa Ishikawa, Toshiaki Nonami, Satoru Sugiyama |
Abstract |
Nitric oxide (NO) has been reported to be a key mediator in hepatocyte proliferation during liver regeneration. NO is the oxidative metabolite of L-arginine, and is produced by a family of enzymes, collective termed nitric oxide synthase (NOS). Thus, administration of L-arginine might enhance liver regeneration after a hepatectomy. Another amino acid, L-glutamine, which plays an important role in catabolic states and is a crucial factor in various cellular and organ functions, is widely known to enhance liver regeneration experimentally. Thus, the present study was undertaken to evaluate the effects of an L-arginine supplement on liver regeneration, and to compared this with supplementation with L-glutamine and L-alanine (the latter as a negative control), using a rat partial hepatectomy model. |
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