Title |
Expression of prolactin receptors in normal canine mammary tissue, canine mammary adenomas and mammary adenocarcinomas
|
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Published in |
BMC Veterinary Research, May 2012
|
DOI | 10.1186/1746-6148-8-72 |
Pubmed ID | |
Authors |
Erika Michel, Stefanie K Feldmann, Mariusz P Kowalewski, Carla Rohrer Bley, Alois Boos, Franco Guscetti, Iris M Reichler |
Abstract |
Mammary tumors represent the most common neoplastic disease in female dogs. Recently, the promoting role of prolactin (PRL) in the development of human breast carcinoma has been shown. Possible proliferative, anti-apoptotic, migratory and angiogenic effects of PRL on human mammary cancer cells in vitro and in vivo were suggested. The effects of PRL are mediated by its receptor, and alterations in receptor expression are likely to play a role in tumor development. Currently, not much data is available about prolactin receptor (PRLR) expression in canine mammary tumors. To set the basis for investigations on the role of PRL in mammary tumorigenesis in this species, prolactin receptor expression was evaluated by semi-quantitative real time PCR and immunohistochemistry on 10 formalin-fixed, paraffin-embedded samples each of canine non-neoplastic mammary tissue, mammary adenomas and adenocarcinomas. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 40% |
Grenada | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Unknown | 46 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 11 | 23% |
Student > Doctoral Student | 6 | 13% |
Other | 5 | 11% |
Researcher | 4 | 9% |
Student > Postgraduate | 4 | 9% |
Other | 10 | 21% |
Unknown | 7 | 15% |
Readers by discipline | Count | As % |
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Veterinary Science and Veterinary Medicine | 20 | 43% |
Medicine and Dentistry | 8 | 17% |
Agricultural and Biological Sciences | 8 | 17% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Linguistics | 1 | 2% |
Other | 0 | 0% |
Unknown | 9 | 19% |