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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Glimpse into the future: harnessing autophagy to promote anti-tumor immunity with the DRibbles vaccine
|
|---|---|
| Published in |
Journal for Immunotherapy of Cancer, May 2016
|
| DOI | 10.1186/s40425-016-0130-4 |
| Pubmed ID | |
| Authors |
David B. Page, Tyler W. Hulett, Traci L. Hilton, Hong-Ming Hu, Walter J. Urba, Bernard A. Fox |
| Abstract |
Because the benefits of immune checkpoint blockade may be restricted to tumors with pre-existing immune recognition, novel therapies that facilitate de novo immune activation are needed. DRibbles is a novel multi-valent vaccine that is created by disrupting degradation of intracellular proteins by the ubiquitin proteasome system. The DRibbles vaccine is comprised of autophagosome vesicles that are enriched with defective ribosomal products and short-lived proteins, known tumor-associated antigens, mediators of innate immunity, and surface markers that encourage phagocytosis and cross-presentation by antigen presenting cells. Here we summarize the rationale and preclinical development of DRibbles, translational evidence in support of DRibbles as a therapeutic strategy in humans, as well as recent developments and expected future directions of the DRibbles vaccine in the clinic. |
X Demographics
The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 40% |
| Germany | 2 | 10% |
| Poland | 1 | 5% |
| Italy | 1 | 5% |
| United Kingdom | 1 | 5% |
| Pakistan | 1 | 5% |
| Unknown | 6 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 75% |
| Scientists | 3 | 15% |
| Practitioners (doctors, other healthcare professionals) | 2 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 35 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 23% |
| Student > Master | 6 | 17% |
| Student > Bachelor | 4 | 11% |
| Student > Ph. D. Student | 3 | 9% |
| Other | 3 | 9% |
| Other | 3 | 9% |
| Unknown | 8 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 23% |
| Biochemistry, Genetics and Molecular Biology | 6 | 17% |
| Immunology and Microbiology | 5 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
| Psychology | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 11 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2020.
All research outputs
#1,625,915
of 25,734,859 outputs
Outputs from Journal for Immunotherapy of Cancer
#412
of 3,498 outputs
Outputs of similar age
#27,968
of 343,386 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#3
of 15 outputs
Altmetric has tracked 25,734,859 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,498 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,386 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.