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Fibrosis in systemic sclerosis: common and unique pathobiology

Overview of attention for article published in Fibrogenesis & Tissue Repair, June 2012
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1 tweeter

Citations

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31 Dimensions

Readers on

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71 Mendeley
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Title
Fibrosis in systemic sclerosis: common and unique pathobiology
Published in
Fibrogenesis & Tissue Repair, June 2012
DOI 10.1186/1755-1536-5-s1-s18
Pubmed ID
Authors

Swati Bhattacharyya, Jun Wei, Warren G Tourtellotte, Monique Hinchcliff, Cara G Gottardi, John Varga

Abstract

Fibrosis in systemic sclerosis (SSc), a complex polygenic disease associated with autoimmunity and proliferative/obliterative vasculopathy, shares pathobiologic features in common with other fibrosing illnesses, but also has distinguishing characteristics. Fibroblast activation induced by transforming growth factor-β (TGF-β), Wnts and innate immune receptors, along with oxidative stress and reactive oxygen species (ROS) are implicated in pathogenesis. On the other hand, the roles of endothelial-mesenchymal differentiation and bone marrow-derived fibrocytes remain to be established. Fibrotic responses are modulated by transcriptional activators and cofactors, epigenetic factors, and microRNAs that can amplify or inhibit ligand-induced signaling. The nuclear orphan receptor PPAR-γ appears to be important in governing the duration and intensity of fibroblast activation and mesenchymal progenitor cell differentiation, and defects in PPAR-γ expression or function in SSc may underlie the uncontrolled progression of fibrosis. Identifying the perturbations in signaling pathways and cellular differentiation programs responsible for tissue damage and fibrosis in SSc allows their selective targeting using novel compounds, or by innovative uses of already-approved drugs (drug repurposing).

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Portugal 1 1%
Germany 1 1%
Unknown 68 96%

Demographic breakdown

Readers by professional status Count As %
Other 13 18%
Student > Ph. D. Student 8 11%
Researcher 8 11%
Student > Master 7 10%
Student > Bachelor 6 8%
Other 13 18%
Unknown 16 23%
Readers by discipline Count As %
Medicine and Dentistry 19 27%
Biochemistry, Genetics and Molecular Biology 15 21%
Agricultural and Biological Sciences 10 14%
Nursing and Health Professions 3 4%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Other 4 6%
Unknown 17 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2012.
All research outputs
#15,055,021
of 18,796,975 outputs
Outputs from Fibrogenesis & Tissue Repair
#66
of 80 outputs
Outputs of similar age
#103,081
of 137,465 outputs
Outputs of similar age from Fibrogenesis & Tissue Repair
#1
of 1 outputs
Altmetric has tracked 18,796,975 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 80 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 137,465 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them