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Mendeley readers
| Title |
Invasive breast cancer induces laminin-332 upregulation and integrin β4 neoexpression in myofibroblasts to confer an anoikis-resistant phenotype during tissue remodeling
|
|---|---|
| Published in |
Breast Cancer Research, June 2012
|
| DOI | 10.1186/bcr3203 |
| Pubmed ID | |
| Authors |
Baek Gil Kim, Ming-Qing Gao, Yoon Pyo Choi, Suki Kang, Haeng Ran Park, Kyu Sub Kang, Nam Hoon Cho |
| Abstract |
Although development of anoikis-resistant myofibroblasts during tissue remodeling is known to be associated with tumor invasion, the mechanism by which myofibroblasts become resistant to anoikis is unknown. We previously demonstrated laminin-332 upregulation in the fibrosis around invasive ductal carcinoma (IDC). Because laminin-332 promotes cell survival through binding to integrins, we hypothesized that invasive breast cancer cells confer an anoikis-resistant phenotype on myofibroblasts by upregulating laminin-332 expression during tissue remodeling. Here, we demonstrate that invasive breast cancer cells induce laminin-332 upregulation and integrin β4 neoexpression in myofibroblasts to confer an anoikis-resistant phenotype. |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 2% |
| Unknown | 59 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 23% |
| Student > Master | 11 | 18% |
| Researcher | 7 | 12% |
| Student > Bachelor | 4 | 7% |
| Professor | 4 | 7% |
| Other | 9 | 15% |
| Unknown | 11 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 23% |
| Biochemistry, Genetics and Molecular Biology | 13 | 22% |
| Medicine and Dentistry | 6 | 10% |
| Immunology and Microbiology | 3 | 5% |
| Engineering | 3 | 5% |
| Other | 6 | 10% |
| Unknown | 15 | 25% |