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Mendeley readers
| Title |
Somatic VHLgene alterations in MEN2-associated medullary thyroid carcinoma
|
|---|---|
| Published in |
BMC Cancer, May 2006
|
| DOI | 10.1186/1471-2407-6-131 |
| Pubmed ID | |
| Authors |
Christian A Koch, Frederieke M Brouwers, Alexander O Vortmeyer, Andrea Tannapfel, Steven K Libutti, Zhengping Zhuang, Karel Pacak, Hartmut PH Neumann, Ralf Paschke |
| Abstract |
Germline mutations in RET are responsible for multiple endocrine neoplasia type 2 (MEN2), an autosomal dominantly inherited cancer syndrome that is characterized by medullary thyroid carcinoma (MTC), pheochromocytoma, and parathyroid hyperplasia/adenoma. Recent studies suggest a "second hit" mechanism resulting in amplification of mutant RET. Somatic VHL gene alterations are implicated in the pathogenesis of MEN2 pheochromocytomas. We hypothesized that somatic VHL gene alterations are also important in the pathogenesis of MEN2-associated MTC. |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Czechia | 1 | 3% |
| France | 1 | 3% |
| Unknown | 28 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 27% |
| Professor > Associate Professor | 5 | 17% |
| Other | 4 | 13% |
| Student > Master | 4 | 13% |
| Student > Ph. D. Student | 2 | 7% |
| Other | 2 | 7% |
| Unknown | 5 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 23% |
| Agricultural and Biological Sciences | 5 | 17% |
| Biochemistry, Genetics and Molecular Biology | 4 | 13% |
| Nursing and Health Professions | 2 | 7% |
| Neuroscience | 2 | 7% |
| Other | 2 | 7% |
| Unknown | 8 | 27% |