Title |
Immunodominant fragments of myelin basic protein initiate T cell-dependent pain
|
---|---|
Published in |
Journal of Neuroinflammation, June 2012
|
DOI | 10.1186/1742-2094-9-119 |
Pubmed ID | |
Authors |
Huaqing Liu, Sergey A Shiryaev, Andrei V Chernov, Youngsoon Kim, Igor Shubayev, Albert G Remacle, Svetlana Baranovskaya, Vladislav S Golubkov, Alex Y Strongin, Veronica I Shubayev |
Abstract |
The myelin sheath provides electrical insulation of mechanosensory Aβ-afferent fibers. Myelin-degrading matrix metalloproteinases (MMPs) damage the myelin sheath. The resulting electrical instability of Aβ-fibers is believed to activate the nociceptive circuitry in Aβ-fibers and initiate pain from innocuous tactile stimulation (mechanical allodynia). The precise molecular mechanisms, responsible for the development of this neuropathic pain state after nerve injury (for example, chronic constriction injury, CCI), are not well understood. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
United States | 1 | 2% |
Unknown | 60 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 18% |
Researcher | 11 | 18% |
Other | 7 | 11% |
Student > Bachelor | 7 | 11% |
Student > Doctoral Student | 5 | 8% |
Other | 12 | 19% |
Unknown | 9 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 29% |
Neuroscience | 11 | 18% |
Agricultural and Biological Sciences | 8 | 13% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Engineering | 3 | 5% |
Other | 7 | 11% |
Unknown | 12 | 19% |