Title |
Reference-free SNP calling: improved accuracy by preventing incorrect calls from repetitive genomic regions
|
---|---|
Published in |
Biology Direct, June 2012
|
DOI | 10.1186/1745-6150-7-17 |
Pubmed ID | |
Authors |
Jinzhuang Dou, Xiqiang Zhao, Xiaoteng Fu, Wenqian Jiao, Nannan Wang, Lingling Zhang, Xiaoli Hu, Shi Wang, Zhenmin Bao |
Abstract |
Single nucleotide polymorphisms (SNPs) are the most abundant type of genetic variation in eukaryotic genomes and have recently become the marker of choice in a wide variety of ecological and evolutionary studies. The advent of next-generation sequencing (NGS) technologies has made it possible to efficiently genotype a large number of SNPs in the non-model organisms with no or limited genomic resources. Most NGS-based genotyping methods require a reference genome to perform accurate SNP calling. Little effort, however, has yet been devoted to developing or improving algorithms for accurate SNP calling in the absence of a reference genome. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
Colombia | 1 | 1% |
Germany | 1 | 1% |
India | 1 | 1% |
Brazil | 1 | 1% |
Belgium | 1 | 1% |
United Kingdom | 1 | 1% |
Unknown | 83 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 27 | 30% |
Student > Ph. D. Student | 20 | 22% |
Student > Master | 18 | 20% |
Student > Doctoral Student | 5 | 5% |
Other | 5 | 5% |
Other | 13 | 14% |
Unknown | 3 | 3% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 60 | 66% |
Biochemistry, Genetics and Molecular Biology | 6 | 7% |
Environmental Science | 4 | 4% |
Computer Science | 4 | 4% |
Medicine and Dentistry | 3 | 3% |
Other | 6 | 7% |
Unknown | 8 | 9% |