Title |
Genes associated with MUC5AC expression in small airway epithelium of human smokers and non-smokers
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Published in |
BMC Medical Genomics, June 2012
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DOI | 10.1186/1755-8794-5-21 |
Pubmed ID | |
Authors |
Guoqing Wang, Zhibo Xu, Rui Wang, Mohammed Al-Hijji, Jacqueline Salit, Yael Strulovici-Barel, Ann E Tilley, Jason G Mezey, Ronald G Crystal |
Abstract |
Mucus hypersecretion contributes to the morbidity and mortality of smoking-related lung diseases, especially chronic obstructive pulmonary disease (COPD), which starts in the small airways. Despite progress in animal studies, the genes and their expression pattern involved in mucus production and secretion in human airway epithelium are not well understood. We hypothesized that comparison of the transcriptomes of the small airway epithelium of individuals that express high vs low levels of MUC5AC, the major macromolecular component of airway mucus, could be used as a probe to identify the genes related to human small airway mucus production/secretion. |
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Australia | 1 | 50% |
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Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
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France | 1 | 2% |
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Researcher | 11 | 17% |
Student > Bachelor | 8 | 13% |
Student > Master | 5 | 8% |
Student > Doctoral Student | 4 | 6% |
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Unknown | 9 | 14% |
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Computer Science | 1 | 2% |
Other | 6 | 10% |
Unknown | 9 | 14% |