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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Prenatal activation of Toll-like receptors-3 by administration of the viral mimetic poly(I:C) changes synaptic proteins, N-methyl-D-aspartate receptors and neurogenesis markers in offspring
|
|---|---|
| Published in |
Molecular Brain, June 2012
|
| DOI | 10.1186/1756-6606-5-22 |
| Pubmed ID | |
| Authors |
Caroline M Forrest, Omari S Khalil, Mazura Pisar, Robert A Smith, Lynda Gail Darlington, Trevor W Stone |
| Abstract |
There is mounting evidence for a neurodevelopmental basis for disorders such as autism and schizophrenia, in which prenatal or early postnatal events may influence brain development and predispose the young to develop these and related disorders. We have now investigated the effect of a prenatal immune challenge on brain development in the offspring. Pregnant rats were treated with the double-stranded RNA polyinosinic:polycytidylic acid (poly(I:C); 10 mg/kg) which mimics immune activation occurring after activation of Toll-like receptors-3 (TLR3) by viral infection. Injections were made in late gestation (embryonic days E14, E16 and E18), after which parturition proceeded naturally and the young were allowed to develop up to the time of weaning at postnatal day 21 (P21). The brains of these animals were then removed to assess the expression of 13 different neurodevelopmental molecules by immunoblotting. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 133 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Italy | 1 | <1% |
| Austria | 1 | <1% |
| Unknown | 129 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 16% |
| Student > Bachelor | 21 | 16% |
| Researcher | 16 | 12% |
| Student > Master | 15 | 11% |
| Professor > Associate Professor | 11 | 8% |
| Other | 21 | 16% |
| Unknown | 28 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 31 | 23% |
| Neuroscience | 27 | 20% |
| Medicine and Dentistry | 17 | 13% |
| Psychology | 6 | 5% |
| Biochemistry, Genetics and Molecular Biology | 5 | 4% |
| Other | 12 | 9% |
| Unknown | 35 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2012.
All research outputs
#20,880,816
of 25,654,806 outputs
Outputs from Molecular Brain
#926
of 1,204 outputs
Outputs of similar age
#141,945
of 181,152 outputs
Outputs of similar age from Molecular Brain
#12
of 12 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,204 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 181,152 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.