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Anti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance

Overview of attention for article published in Arthritis Research & Therapy, June 2012
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (76th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

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9 X users

Citations

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140 Dimensions

Readers on

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136 Mendeley
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Title
Anti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance
Published in
Arthritis Research & Therapy, June 2012
DOI 10.1186/ar3874
Pubmed ID
Authors

Ilias Stagakis, George Bertsias, Stylianos Karvounaris, Melina Kavousanaki, Dimitra Virla, Amalia Raptopoulou, Dimitrios Kardassis, Dimitrios T Boumpas, Prodromos I Sidiropoulos

Abstract

Prevalence of insulin resistance and the metabolic syndrome has been reported to be high in rheumatoid arthritis (RA) patients. Tumor necrosis factor (TNF), a pro-inflammatory cytokine with a major pathogenetic role in RA, may promote insulin resistance by inducing Ser312 phosphorylation (p-Ser312) of insulin receptor substrate (IRS)-1 and downregulating phosphorylated (p-)AKT. We examined whether anti-TNF therapy improves insulin resistance in RA patients and assessed changes in the insulin signaling cascade.

X Demographics

X Demographics

The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 2%
Russia 1 <1%
Brazil 1 <1%
Unknown 131 96%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 18 13%
Student > Ph. D. Student 14 10%
Student > Master 13 10%
Student > Bachelor 12 9%
Researcher 11 8%
Other 38 28%
Unknown 30 22%
Readers by discipline Count As %
Medicine and Dentistry 61 45%
Pharmacology, Toxicology and Pharmaceutical Science 9 7%
Agricultural and Biological Sciences 8 6%
Nursing and Health Professions 6 4%
Biochemistry, Genetics and Molecular Biology 5 4%
Other 11 8%
Unknown 36 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2012.
All research outputs
#6,333,243
of 25,374,647 outputs
Outputs from Arthritis Research & Therapy
#1,374
of 3,381 outputs
Outputs of similar age
#43,052
of 180,999 outputs
Outputs of similar age from Arthritis Research & Therapy
#15
of 76 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 180,999 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.