Title |
Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes
|
---|---|
Published in |
BMC Genomics, November 2010
|
DOI | 10.1186/1471-2164-11-667 |
Pubmed ID | |
Authors |
John HE Nash, Andre Villegas, Andrew M Kropinski, Renan Aguilar-Valenzuela, Paulina Konczy, Mariola Mascarenhas, Kim Ziebell, Alfredo G Torres, Mohamed A Karmali, Brian K Coombes |
Abstract |
Adherent and invasive Escherichia coli (AIEC) are commonly found in ileal lesions of Crohn's Disease (CD) patients, where they adhere to intestinal epithelial cells and invade into and survive in epithelial cells and macrophages, thereby gaining access to a typically restricted host niche. Colonization leads to strong inflammatory responses in the gut suggesting that AIEC could play a role in CD immunopathology. Despite extensive investigation, the genetic determinants accounting for the AIEC phenotype remain poorly defined. To address this, we present the complete genome sequence of an AIEC, revealing the genetic blueprint for this disease-associated E. coli pathotype. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 2% |
Indonesia | 1 | <1% |
France | 1 | <1% |
Tanzania, United Republic of | 1 | <1% |
South Africa | 1 | <1% |
Ireland | 1 | <1% |
Canada | 1 | <1% |
United Kingdom | 1 | <1% |
Unknown | 212 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 43 | 19% |
Researcher | 36 | 16% |
Student > Bachelor | 35 | 16% |
Student > Master | 26 | 12% |
Other | 13 | 6% |
Other | 33 | 15% |
Unknown | 37 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 77 | 35% |
Biochemistry, Genetics and Molecular Biology | 44 | 20% |
Immunology and Microbiology | 31 | 14% |
Medicine and Dentistry | 14 | 6% |
Computer Science | 3 | 1% |
Other | 13 | 6% |
Unknown | 41 | 18% |