Title |
Increased HOX C13 expression in metastatic melanoma progression
|
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Published in |
Journal of Translational Medicine, May 2012
|
DOI | 10.1186/1479-5876-10-91 |
Pubmed ID | |
Authors |
Monica Cantile, Giosuè Scognamiglio, Annamaria Anniciello, Marisa Farina, Giusy Gentilcore, Clemente Santonastaso, Franco Fulciniti, Clemente Cillo, Renato Franco, Paolo A Ascierto, Gerardo Botti |
Abstract |
The process of malignant transformation, progression and metastasis of melanoma is not completely understood. Recently, the microarray technology has been used to survey transcriptional differences that might provide insight into the metastatic process, but the validation of changing gene expression during metastatic transition period is poorly investigated. A large body of literature has been produced on the role of the HOX genes network in tumour evolution, suggesting the involvement of HOX genes in several types of human cancers. Deregulated paralogous group 13 HOX genes expression has been detected in melanoma, cervical cancer and odonthogenic tumors. Among these, Hox C13 is also involved in the expression control of the human keratin genes hHa5 and hHa2, and recently it was identified as a member of human DNA replication complexes. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 4% |
Unknown | 22 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 22% |
Researcher | 4 | 17% |
Student > Ph. D. Student | 4 | 17% |
Student > Doctoral Student | 2 | 9% |
Professor | 2 | 9% |
Other | 2 | 9% |
Unknown | 4 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 8 | 35% |
Biochemistry, Genetics and Molecular Biology | 5 | 22% |
Medicine and Dentistry | 4 | 17% |
Immunology and Microbiology | 1 | 4% |
Unknown | 5 | 22% |