Title |
Immunohistochemical investigation of cell cycle and apoptosis regulators (Survivin, β-Catenin, P53, Caspase 3) in canine appendicular osteosarcoma
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Published in |
BMC Veterinary Research, June 2012
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DOI | 10.1186/1746-6148-8-78 |
Pubmed ID | |
Authors |
Laura Bongiovanni, Francesca Mazzocchetti, Daniela Malatesta, Mariarita Romanucci, Andrea Ciccarelli, Paolo Buracco, Raffaella De Maria, Chiara Palmieri, Marina Martano, Emanuela Morello, Lorella Maniscalco, Leonardo Della Salda |
Abstract |
Osteosarcoma (OSA) represents the most common canine primary bone tumour. Despite several pathways have been investigated so far, few molecules have been identified as prognostic tools or potential therapeutic targets, and there is still the need to find out molecular pathways with specific influence over OSA progression to facilitate earlier prognosis and treatment.Aims of the present study were to evaluate the immunohistochemical pattern and levels of expression of a panel of molecules (survivin, β-catenin, caspase 3 -inactive and active forms- and p53) involved in cell cycle and apoptosis regulation in canine OSA samples, known to be of interest in the study also of human OSA, and to detect specific relations among them and with histological tumour grade, disease free interval (DFI) and overall survival (OS). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Unknown | 53 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Postgraduate | 8 | 15% |
Student > Master | 8 | 15% |
Researcher | 7 | 13% |
Other | 7 | 13% |
Professor > Associate Professor | 5 | 9% |
Other | 13 | 24% |
Unknown | 6 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 26 | 48% |
Medicine and Dentistry | 11 | 20% |
Engineering | 2 | 4% |
Computer Science | 1 | 2% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Other | 2 | 4% |
Unknown | 11 | 20% |