Title |
On the origin of Mycobacterium ulcerans, the causative agent of Buruli ulcer
|
---|---|
Published in |
BMC Genomics, June 2012
|
DOI | 10.1186/1471-2164-13-258 |
Pubmed ID | |
Authors |
Kenneth D Doig, Kathryn E Holt, Janet AM Fyfe, Caroline J Lavender, Miriam Eddyani, Françoise Portaels, Dorothy Yeboah-Manu, Gerd Pluschke, Torsten Seemann, Timothy P Stinear |
Abstract |
Mycobacterium ulcerans is an unusual bacterial pathogen with elusive origins. While closely related to the aquatic dwelling M. marinum, M. ulcerans has evolved the ability to produce the immunosuppressive polyketide toxin mycolactone and cause the neglected tropical disease Buruli ulcer. Other mycolactone-producing mycobacteria (MPM) have been identified in fish and frogs and given distinct species designations (M. pseudoshottsii, M. shinshuense, M. liflandii and M. marinum), however the evolution of M. ulcerans and its relationship to other MPM has not been defined. Here we report the comparative analysis of whole genome sequences from 30 MPM and five M. marinum. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | <1% |
Sweden | 1 | <1% |
Uganda | 1 | <1% |
Belgium | 1 | <1% |
Unknown | 151 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 30 | 19% |
Student > Bachelor | 24 | 15% |
Student > Ph. D. Student | 23 | 15% |
Student > Master | 18 | 12% |
Student > Doctoral Student | 11 | 7% |
Other | 21 | 14% |
Unknown | 28 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 39 | 25% |
Biochemistry, Genetics and Molecular Biology | 27 | 17% |
Medicine and Dentistry | 23 | 15% |
Immunology and Microbiology | 13 | 8% |
Engineering | 6 | 4% |
Other | 15 | 10% |
Unknown | 32 | 21% |