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Inhibitor of neuronal nitric oxide synthase improves gas exchange in ventilator-induced lung injury after pneumonectomy

Overview of attention for article published in BMC Anesthesiology, June 2012
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Title
Inhibitor of neuronal nitric oxide synthase improves gas exchange in ventilator-induced lung injury after pneumonectomy
Published in
BMC Anesthesiology, June 2012
DOI 10.1186/1471-2253-12-10
Pubmed ID
Authors

Evgeny V Suborov, Alexey A Smetkin, Timofey V Kondratiev, Andrey Y Valkov, Vsevolod V Kuzkov, Mikhail Y Kirov, Lars J Bjertnaes

Abstract

Mechanical ventilation with high tidal volumes may cause ventilator-induced lung injury (VILI) and enhanced generation of nitric oxide (NO). We demonstrated in sheep that pneumonectomy followed by injurious ventilation promotes pulmonary edema. We wished both to test the hypothesis that neuronal NOS (nNOS), which is distributed in airway epithelial and neuronal tissues, could be involved in the pathogenesis of VILI and we also aimed at investigating the influence of an inhibitor of nNOS on the course of VILI after pneumonectomy.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 67%
Professor 1 11%
Unknown 2 22%
Readers by discipline Count As %
Medicine and Dentistry 6 67%
Unknown 3 33%