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Celiac disease T-cell epitopes from gamma-gliadins: immunoreactivity depends on the genome of origin, transcript frequency, and flanking protein variation

Overview of attention for article published in BMC Genomics, June 2012
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

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1 news outlet
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1 X user
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1 Facebook page

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76 Mendeley
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1 CiteULike
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Title
Celiac disease T-cell epitopes from gamma-gliadins: immunoreactivity depends on the genome of origin, transcript frequency, and flanking protein variation
Published in
BMC Genomics, June 2012
DOI 10.1186/1471-2164-13-277
Pubmed ID
Authors

Elma MJ Salentijn, D Cristina Mitea, Svetlana V Goryunova, Ingrid M van der Meer, Ismael Padioleau, Luud JWJ Gilissen, Frits Koning, Marinus JM Smulders

Abstract

Celiac disease (CD) is caused by an uncontrolled immune response to gluten, a heterogeneous mixture of wheat storage proteins. The CD-toxicity of these proteins and their derived peptides is depending on the presence of specific T-cell epitopes (9-mer peptides; CD epitopes) that mediate the stimulation of HLA-DQ2/8 restricted T-cells. Next to the thoroughly characterized major T-cell epitopes derived from the α-gliadin fraction of gluten, γ-gliadin peptides are also known to stimulate T-cells of celiac disease patients. To pinpoint CD-toxic γ-gliadins in hexaploid bread wheat, we examined the variation of T-cell epitopes involved in CD in γ-gliadin transcripts of developing bread wheat grains.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 5%
Italy 1 1%
Germany 1 1%
Canada 1 1%
Paraguay 1 1%
Unknown 68 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 24 32%
Student > Ph. D. Student 10 13%
Student > Bachelor 8 11%
Student > Doctoral Student 5 7%
Professor > Associate Professor 5 7%
Other 14 18%
Unknown 10 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 39 51%
Biochemistry, Genetics and Molecular Biology 6 8%
Immunology and Microbiology 5 7%
Nursing and Health Professions 3 4%
Medicine and Dentistry 3 4%
Other 10 13%
Unknown 10 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2018.
All research outputs
#3,080,569
of 25,373,627 outputs
Outputs from BMC Genomics
#956
of 11,244 outputs
Outputs of similar age
#19,545
of 177,754 outputs
Outputs of similar age from BMC Genomics
#11
of 159 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,244 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 177,754 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 159 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.