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When is it rational to participate in a clinical trial? A game theory approach incorporating trust, regret and guilt

Overview of attention for article published in BMC Medical Research Methodology, June 2012
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Title
When is it rational to participate in a clinical trial? A game theory approach incorporating trust, regret and guilt
Published in
BMC Medical Research Methodology, June 2012
DOI 10.1186/1471-2288-12-85
Pubmed ID
Authors

Benjamin Djulbegovic, Iztok Hozo

Abstract

Randomized controlled trials (RCTs) remain an indispensable form of human experimentation as a vehicle for discovery of new treatments. However, since their inception RCTs have raised ethical concerns. The ethical tension has revolved around "duties to individuals" vs. "societal value" of RCTs. By asking current patients "to sacrifice for the benefit of future patients" we risk subjugating our duties to patients' best interest to the utilitarian goal for the good of others. This tension creates a key dilemma: when is it rational, from the perspective of the trial patients and researchers (as societal representatives of future patients), to enroll in RCTs?

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 1 2%
Unknown 64 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 17%
Researcher 10 15%
Student > Ph. D. Student 10 15%
Student > Doctoral Student 5 8%
Student > Bachelor 5 8%
Other 12 18%
Unknown 12 18%
Readers by discipline Count As %
Medicine and Dentistry 15 23%
Nursing and Health Professions 6 9%
Social Sciences 6 9%
Psychology 6 9%
Philosophy 3 5%
Other 15 23%
Unknown 14 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2012.
All research outputs
#15,557,505
of 23,881,329 outputs
Outputs from BMC Medical Research Methodology
#1,512
of 2,109 outputs
Outputs of similar age
#103,784
of 166,045 outputs
Outputs of similar age from BMC Medical Research Methodology
#22
of 32 outputs
Altmetric has tracked 23,881,329 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,109 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 166,045 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.