Title |
Molecular responses to hypoxia in tumor cells
|
---|---|
Published in |
Molecular Cancer, April 2003
|
DOI | 10.1186/1476-4598-2-23 |
Pubmed ID | |
Authors |
Manfred Kunz, Saleh M Ibrahim |
Abstract |
Highly aggressive, rapidly growing tumors are exposed to hypoxia or even anoxia which occurs as a consequence of inadequate blood supply. Both hypoxia and consecutive hypoxia/reoxygenation exert a variety of influences on tumor cell biology. Among these are activation of certain signal transduction pathways and gene regulatory mechanisms, induction of selection processes for gene mutations, tumor cell apoptosis and tumor angiogenesis. Most of these mechanisms contribute to tumor progression. Therefore, tissue hypoxia has been regarded as a central factor for tumor aggressiveness and metastasis. In this review, we summarize the current knowledge about the molecular mechanisms induced by tumor cell hypoxia with a special emphasis on intracellular signal transduction, gene regulation, angiogenesis and apoptosis. Interfering with these pathways might open perspectives for future innovative treatment of highly aggressive metastasizing tumors. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | 2% |
Portugal | 2 | 2% |
United Kingdom | 2 | 2% |
United States | 2 | 2% |
Spain | 2 | 2% |
Ireland | 1 | <1% |
Brazil | 1 | <1% |
Netherlands | 1 | <1% |
Canada | 1 | <1% |
Other | 3 | 3% |
Unknown | 103 | 86% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 28 | 23% |
Researcher | 23 | 19% |
Student > Master | 21 | 18% |
Student > Bachelor | 12 | 10% |
Professor > Associate Professor | 8 | 7% |
Other | 18 | 15% |
Unknown | 10 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 40 | 33% |
Biochemistry, Genetics and Molecular Biology | 26 | 22% |
Medicine and Dentistry | 26 | 22% |
Chemistry | 5 | 4% |
Engineering | 3 | 3% |
Other | 8 | 7% |
Unknown | 12 | 10% |