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Metabolomic investigation of regional brain tissue dysfunctions induced by global cerebral ischemia

Overview of attention for article published in BMC Neuroscience, May 2016
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Title
Metabolomic investigation of regional brain tissue dysfunctions induced by global cerebral ischemia
Published in
BMC Neuroscience, May 2016
DOI 10.1186/s12868-016-0256-9
Pubmed ID
Authors

Tianshu Zhang, Wei Wang, Jin Huang, Xia Liu, Haiyan Zhang, Naixia Zhang

Abstract

To get a broader view of global ischemia-induced cerebral disorders at the metabolic level, a nuclear magnetic resonance-based metabolomic study was performed to evaluate the metabolic profile changes on regional brain tissues of female and male mice upon bilateral common carotid arteries occlusion (BCCAO) operation. Significant metabolic disorders were observed in both cerebral cortex and hippocampus tissues of the experimental mice upon global cerebral ischemic attack. Multiple amino acids were identified as the dominantly perturbed metabolites. It was also shown that although the metabolic profile change patterns in the brain tissues were quite similar in male and female BCCAO mice, metabolic disorders in the cortex tissues were more severe in the female mice than in the male mice. In the present study, significant changes in amino acid metabolic pathways were confirmed in the early stage of global ischemia. Meanwhile, cerebral metabolic dysfunctions were more severe in the female BCCAO mice than in the male mice, suggesting that gender may play a role in different metabolic responses to the ischemic attack, which may provide an important hypothesis for a better understanding of the clinically observed gender-dependent pathological outcome of cerebral ischemia.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 25%
Other 3 15%
Researcher 3 15%
Professor > Associate Professor 2 10%
Student > Master 2 10%
Other 3 15%
Unknown 2 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 25%
Medicine and Dentistry 4 20%
Biochemistry, Genetics and Molecular Biology 3 15%
Neuroscience 3 15%
Psychology 1 5%
Other 1 5%
Unknown 3 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2017.
All research outputs
#9,434,880
of 11,805,285 outputs
Outputs from BMC Neuroscience
#684
of 962 outputs
Outputs of similar age
#194,804
of 278,272 outputs
Outputs of similar age from BMC Neuroscience
#15
of 32 outputs
Altmetric has tracked 11,805,285 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 962 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.