Title |
A novel method to identify high order gene-gene interactions in genome-wide association studies: Gene-based MDR
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Published in |
BMC Bioinformatics, June 2012
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DOI | 10.1186/1471-2105-13-s9-s5 |
Pubmed ID | |
Authors |
Sohee Oh, Jaehoon Lee, Min-Seok Kwon, Bruce Weir, Kyooseob Ha, Taesung Park |
Abstract |
Because common complex diseases are affected by multiple genes and environmental factors, it is essential to investigate gene-gene and/or gene-environment interactions to understand genetic architecture of complex diseases. After the great success of large scale genome-wide association (GWA) studies using the high density single nucleotide polymorphism (SNP) chips, the study of gene-gene interaction becomes a next challenge. Multifactor dimensionality reduction (MDR) analysis has been widely used for the gene-gene interaction analysis. In practice, however, it is not easy to perform high order gene-gene interaction analyses via MDR in genome-wide level because it requires exploring a huge search space and suffers from a computational burden due to high dimensionality. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 50% |
Switzerland | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 50% |
Members of the public | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | 2% |
United States | 2 | 2% |
Uganda | 1 | 1% |
Moldova, Republic of | 1 | 1% |
France | 1 | 1% |
Unknown | 77 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 26 | 31% |
Researcher | 16 | 19% |
Student > Master | 10 | 12% |
Student > Postgraduate | 5 | 6% |
Professor > Associate Professor | 5 | 6% |
Other | 13 | 15% |
Unknown | 9 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 37 | 44% |
Biochemistry, Genetics and Molecular Biology | 10 | 12% |
Computer Science | 9 | 11% |
Medicine and Dentistry | 7 | 8% |
Mathematics | 4 | 5% |
Other | 6 | 7% |
Unknown | 11 | 13% |