↓ Skip to main content

A novel method to identify high order gene-gene interactions in genome-wide association studies: Gene-based MDR

Overview of attention for article published in BMC Bioinformatics, June 2012
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

Mentioned by

twitter
4 X users

Citations

dimensions_citation
47 Dimensions

Readers on

mendeley
84 Mendeley
citeulike
2 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
A novel method to identify high order gene-gene interactions in genome-wide association studies: Gene-based MDR
Published in
BMC Bioinformatics, June 2012
DOI 10.1186/1471-2105-13-s9-s5
Pubmed ID
Authors

Sohee Oh, Jaehoon Lee, Min-Seok Kwon, Bruce Weir, Kyooseob Ha, Taesung Park

Abstract

Because common complex diseases are affected by multiple genes and environmental factors, it is essential to investigate gene-gene and/or gene-environment interactions to understand genetic architecture of complex diseases. After the great success of large scale genome-wide association (GWA) studies using the high density single nucleotide polymorphism (SNP) chips, the study of gene-gene interaction becomes a next challenge. Multifactor dimensionality reduction (MDR) analysis has been widely used for the gene-gene interaction analysis. In practice, however, it is not easy to perform high order gene-gene interaction analyses via MDR in genome-wide level because it requires exploring a huge search space and suffers from a computational burden due to high dimensionality.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 2%
United States 2 2%
Uganda 1 1%
Moldova, Republic of 1 1%
France 1 1%
Unknown 77 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 31%
Researcher 16 19%
Student > Master 10 12%
Student > Postgraduate 5 6%
Professor > Associate Professor 5 6%
Other 13 15%
Unknown 9 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 37 44%
Biochemistry, Genetics and Molecular Biology 10 12%
Computer Science 9 11%
Medicine and Dentistry 7 8%
Mathematics 4 5%
Other 6 7%
Unknown 11 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2012.
All research outputs
#12,739,534
of 22,669,724 outputs
Outputs from BMC Bioinformatics
#3,750
of 7,247 outputs
Outputs of similar age
#89,292
of 167,347 outputs
Outputs of similar age from BMC Bioinformatics
#52
of 107 outputs
Altmetric has tracked 22,669,724 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,247 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 167,347 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 107 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.