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X Demographics
Mendeley readers
Attention Score in Context
| Title |
MicroRNA-124 as a novel treatment for persistent hyperalgesia
|
|---|---|
| Published in |
Journal of Neuroinflammation, June 2012
|
| DOI | 10.1186/1742-2094-9-143 |
| Pubmed ID | |
| Authors |
Hanneke LDM Willemen, Xiao-Jiao Huo, Qi-Liang Mao-Ying, Jitske Zijlstra, Cobi J Heijnen, Annemieke Kavelaars |
| Abstract |
Chronic pain is often associated with microglia activation in the spinal cord. We recently showed that microglial levels of the kinase G protein-coupled receptor kinase (GRK)2 are reduced in models of chronic pain. We also found that mice with a cell-specific reduction of around 50% in GRK2 level in microglia/macrophages (LysM-GRK2+/- mice) develop prolonged inflammatory hyperalgesia concomitantly with ongoing spinal microglia/macrophage activation. The microRNA miR-124 is thought to keep microglia/macrophages in brain and spinal cord in a quiescent state. In the present study, we investigated the contribution of miR-124 to regulation of hyperalgesia and microglia/macrophage activation in GRK2-deficient mice. In addition, we investigated the effect of miR-124 on chronic inflammatory and neuropathic pain in wild-type (WT) mice. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 92 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 18% |
| Student > Ph. D. Student | 15 | 16% |
| Student > Master | 14 | 15% |
| Student > Bachelor | 11 | 12% |
| Student > Doctoral Student | 6 | 6% |
| Other | 16 | 17% |
| Unknown | 15 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 23% |
| Agricultural and Biological Sciences | 21 | 22% |
| Neuroscience | 14 | 15% |
| Biochemistry, Genetics and Molecular Biology | 6 | 6% |
| Immunology and Microbiology | 3 | 3% |
| Other | 7 | 7% |
| Unknown | 21 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 February 2021.
All research outputs
#13,132,060
of 22,669,724 outputs
Outputs from Journal of Neuroinflammation
#1,398
of 2,605 outputs
Outputs of similar age
#89,723
of 164,520 outputs
Outputs of similar age from Journal of Neuroinflammation
#31
of 58 outputs
Altmetric has tracked 22,669,724 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,605 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,520 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.