↓ Skip to main content

A statistical approach to selecting and confirming validation targets in -omics experiments

Overview of attention for article published in BMC Bioinformatics, June 2012
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

blogs
2 blogs
twitter
11 X users

Citations

dimensions_citation
13 Dimensions

Readers on

mendeley
106 Mendeley
citeulike
8 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
A statistical approach to selecting and confirming validation targets in -omics experiments
Published in
BMC Bioinformatics, June 2012
DOI 10.1186/1471-2105-13-150
Pubmed ID
Authors

Jeffrey T Leek, Margaret A Taub, Jason L Rasgon

Abstract

Genomic technologies are, by their very nature, designed for hypothesis generation. In some cases, the hypotheses that are generated require that genome scientists confirm findings about specific genes or proteins. But one major advantage of high-throughput technology is that global genetic, genomic, transcriptomic, and proteomic behaviors can be observed. Manual confirmation of every statistically significant genomic result is prohibitively expensive. This has led researchers in genomics to adopt the strategy of confirming only a handful of the most statistically significant results, a small subset chosen for biological interest, or a small random subset. But there is no standard approach for selecting and quantitatively evaluating validation targets.

X Demographics

X Demographics

The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 6%
United Kingdom 3 3%
Netherlands 1 <1%
Brazil 1 <1%
Germany 1 <1%
South Africa 1 <1%
Japan 1 <1%
Denmark 1 <1%
Unknown 91 86%

Demographic breakdown

Readers by professional status Count As %
Researcher 37 35%
Student > Ph. D. Student 26 25%
Student > Master 15 14%
Other 7 7%
Professor 6 6%
Other 12 11%
Unknown 3 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 48 45%
Biochemistry, Genetics and Molecular Biology 16 15%
Computer Science 8 8%
Medicine and Dentistry 7 7%
Pharmacology, Toxicology and Pharmaceutical Science 4 4%
Other 16 15%
Unknown 7 7%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2020.
All research outputs
#1,651,546
of 24,980,180 outputs
Outputs from BMC Bioinformatics
#287
of 7,624 outputs
Outputs of similar age
#9,460
of 169,541 outputs
Outputs of similar age from BMC Bioinformatics
#5
of 97 outputs
Altmetric has tracked 24,980,180 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,624 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 169,541 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.