Title |
A statistical approach to selecting and confirming validation targets in -omics experiments
|
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Published in |
BMC Bioinformatics, June 2012
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DOI | 10.1186/1471-2105-13-150 |
Pubmed ID | |
Authors |
Jeffrey T Leek, Margaret A Taub, Jason L Rasgon |
Abstract |
Genomic technologies are, by their very nature, designed for hypothesis generation. In some cases, the hypotheses that are generated require that genome scientists confirm findings about specific genes or proteins. But one major advantage of high-throughput technology is that global genetic, genomic, transcriptomic, and proteomic behaviors can be observed. Manual confirmation of every statistically significant genomic result is prohibitively expensive. This has led researchers in genomics to adopt the strategy of confirming only a handful of the most statistically significant results, a small subset chosen for biological interest, or a small random subset. But there is no standard approach for selecting and quantitatively evaluating validation targets. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 4 | 36% |
United Kingdom | 2 | 18% |
Unknown | 5 | 45% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 55% |
Scientists | 5 | 45% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 6 | 6% |
United Kingdom | 3 | 3% |
Netherlands | 1 | <1% |
Brazil | 1 | <1% |
Germany | 1 | <1% |
South Africa | 1 | <1% |
Japan | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 91 | 86% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 37 | 35% |
Student > Ph. D. Student | 26 | 25% |
Student > Master | 15 | 14% |
Other | 7 | 7% |
Professor | 6 | 6% |
Other | 12 | 11% |
Unknown | 3 | 3% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 48 | 45% |
Biochemistry, Genetics and Molecular Biology | 16 | 15% |
Computer Science | 8 | 8% |
Medicine and Dentistry | 7 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
Other | 16 | 15% |
Unknown | 7 | 7% |