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Mendeley readers
| Title |
17beta-hydroxysteroid dehydrogenase type 1 modulates breast cancer protein profile and impacts cell migration
|
|---|---|
| Published in |
Breast Cancer Research, June 2012
|
| DOI | 10.1186/bcr3207 |
| Pubmed ID | |
| Authors |
Juliette A Aka, Mouna Zerradi, François Houle, Jacques Huot, Sheng-Xiang Lin |
| Abstract |
Human 17beta-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a steroid-converting enzyme that has long been known to play critical roles in estradiol synthesis and more recently in dihydrotestosterone (DHT) inactivation, showing a dual function that promotes breast cancer cell proliferation. Previously, we reported the first observation of the influence of the enzyme on endogenous estrogen-responsive gene expression. Here, we demonstrate the impact of 17β-HSD1 expression on the breast cancer cell proteome and investigate its role in cell migration. |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 40 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 23% |
| Researcher | 7 | 18% |
| Student > Master | 6 | 15% |
| Student > Doctoral Student | 2 | 5% |
| Professor | 2 | 5% |
| Other | 5 | 13% |
| Unknown | 9 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 30% |
| Biochemistry, Genetics and Molecular Biology | 5 | 13% |
| Agricultural and Biological Sciences | 5 | 13% |
| Chemistry | 2 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
| Other | 2 | 5% |
| Unknown | 12 | 30% |