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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy
|
|---|---|
| Published in |
Clinical Epigenetics, May 2016
|
| DOI | 10.1186/s13148-016-0223-4 |
| Pubmed ID | |
| Authors |
Ludovica Morera, Michael Lübbert, Manfred Jung |
| Abstract |
The term epigenetics is defined as heritable changes in gene expression that are not due to alterations of the DNA sequence. In the last years, it has become more and more evident that dysregulated epigenetic regulatory processes have a central role in cancer onset and progression. In contrast to DNA mutations, epigenetic modifications are reversible and, hence, suitable for pharmacological interventions. Reversible histone methylation is an important process within epigenetic regulation, and the investigation of its role in cancer has led to the identification of lysine methyltransferases and demethylases as promising targets for new anticancer drugs. In this review, we describe those enzymes and their inhibitors that have already reached the first stages of clinical trials in cancer therapy, namely the histone methyltransferases DOT1L and EZH2 as well as the demethylase LSD1. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 31% |
| Austria | 1 | 8% |
| United Kingdom | 1 | 8% |
| Germany | 1 | 8% |
| Spain | 1 | 8% |
| France | 1 | 8% |
| Unknown | 4 | 31% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 7 | 54% |
| Members of the public | 6 | 46% |
Mendeley readers
The data shown below were compiled from readership statistics for 430 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| Spain | 1 | <1% |
| Russia | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 426 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 87 | 20% |
| Researcher | 63 | 15% |
| Student > Master | 51 | 12% |
| Student > Postgraduate | 42 | 10% |
| Student > Bachelor | 41 | 10% |
| Other | 58 | 13% |
| Unknown | 88 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 155 | 36% |
| Agricultural and Biological Sciences | 71 | 17% |
| Chemistry | 35 | 8% |
| Medicine and Dentistry | 31 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 24 | 6% |
| Other | 23 | 5% |
| Unknown | 91 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2023.
All research outputs
#1,197,282
of 23,883,950 outputs
Outputs from Clinical Epigenetics
#54
of 1,343 outputs
Outputs of similar age
#22,741
of 338,561 outputs
Outputs of similar age from Clinical Epigenetics
#3
of 29 outputs
Altmetric has tracked 23,883,950 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,343 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 338,561 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.