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The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis

Overview of attention for article published in Critical Care, August 2011
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Title
The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis
Published in
Critical Care, August 2011
DOI 10.1186/cc10356
Pubmed ID
Authors

Margarita Pérez-Casal, Victoria Thompson, Colin Downey, Ingeborg Welters, Duncan Wyncoll, Jecko Thachil, Cheng Hock Toh

Abstract

Activated protein C (APC) induces release of microparticles (MP) from primary physiological cells, which are found in patients undergoing treatment with recombinant human APC (rhAPC) for severe sepsis. We hypothesised that APC on these circulating MPs activate endothelial protease-activated receptor 1 (PAR1) to induce anti-apoptotic and anti-inflammatory properties that can improve patient outcome.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hungary 1 3%
Portugal 1 3%
Unknown 37 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 15%
Student > Ph. D. Student 5 13%
Student > Bachelor 4 10%
Professor 4 10%
Student > Doctoral Student 4 10%
Other 10 26%
Unknown 6 15%
Readers by discipline Count As %
Medicine and Dentistry 13 33%
Biochemistry, Genetics and Molecular Biology 6 15%
Agricultural and Biological Sciences 6 15%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Immunology and Microbiology 2 5%
Other 3 8%
Unknown 7 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 July 2012.
All research outputs
#19,945,185
of 25,374,917 outputs
Outputs from Critical Care
#5,876
of 6,554 outputs
Outputs of similar age
#107,480
of 131,753 outputs
Outputs of similar age from Critical Care
#48
of 54 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 131,753 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.