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Probe-level linear model fitting and mixture modeling results in high accuracy detection of differential gene expression

Overview of attention for article published in BMC Bioinformatics, August 2006
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Title
Probe-level linear model fitting and mixture modeling results in high accuracy detection of differential gene expression
Published in
BMC Bioinformatics, August 2006
DOI 10.1186/1471-2105-7-391
Pubmed ID
Authors

Sébastien Lemieux

Abstract

The identification of differentially expressed genes (DEGs) from Affymetrix GeneChips arrays is currently done by first computing expression levels from the low-level probe intensities, then deriving significance by comparing these expression levels between conditions. The proposed PL-LM (Probe-Level Linear Model) method implements a linear model applied on the probe-level data to directly estimate the treatment effect. A finite mixture of Gaussian components is then used to identify DEGs using the coefficients estimated by the linear model. This approach can readily be applied to experimental design with or without replication.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 6%
Germany 1 6%
Unknown 15 88%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 53%
Student > Ph. D. Student 4 24%
Student > Postgraduate 2 12%
Professor > Associate Professor 1 6%
Lecturer > Senior Lecturer 1 6%
Other 0 0%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 59%
Computer Science 2 12%
Arts and Humanities 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Physics and Astronomy 1 6%
Other 2 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 July 2012.
All research outputs
#20,160,460
of 22,669,724 outputs
Outputs from BMC Bioinformatics
#6,820
of 7,247 outputs
Outputs of similar age
#64,409
of 66,480 outputs
Outputs of similar age from BMC Bioinformatics
#37
of 38 outputs
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So far Altmetric has tracked 7,247 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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