Title |
Sirtuin functions and modulation: from chemistry to the clinic
|
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Published in |
Clinical Epigenetics, May 2016
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DOI | 10.1186/s13148-016-0224-3 |
Pubmed ID | |
Authors |
Vincenzo Carafa, Dante Rotili, Mariantonietta Forgione, Francesca Cuomo, Enrica Serretiello, Gebremedhin Solomon Hailu, Elina Jarho, Maija Lahtela-Kakkonen, Antonello Mai, Lucia Altucci |
Abstract |
Sirtuins are NAD(+)-dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair, cell metabolism, and caloric restriction. The seven members of this family of enzymes are considered potential targets for the treatment of human pathologies including neurodegenerative diseases, cardiovascular diseases, and cancer. Furthermore, recent interest focusing on sirtuin modulators as epigenetic players in the regulation of fundamental biological pathways has prompted increased efforts to discover new small molecules able to modify sirtuin activity. Here, we review the role, mechanism of action, and biological function of the seven sirtuins, as well as their inhibitors and activators. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 43% |
France | 1 | 14% |
United Kingdom | 1 | 14% |
Unknown | 2 | 29% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 71% |
Scientists | 2 | 29% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | <1% |
Indonesia | 1 | <1% |
United Kingdom | 1 | <1% |
Russia | 1 | <1% |
Spain | 1 | <1% |
Unknown | 347 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 47 | 13% |
Researcher | 44 | 13% |
Student > Bachelor | 44 | 13% |
Student > Master | 42 | 12% |
Student > Doctoral Student | 19 | 5% |
Other | 46 | 13% |
Unknown | 110 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 79 | 22% |
Medicine and Dentistry | 41 | 12% |
Agricultural and Biological Sciences | 39 | 11% |
Chemistry | 25 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 19 | 5% |
Other | 34 | 10% |
Unknown | 115 | 33% |