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Expression and function of pannexins in the inner ear and hearing

Overview of attention for article published in BMC Cell Biology, May 2016
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Title
Expression and function of pannexins in the inner ear and hearing
Published in
BMC Cell Biology, May 2016
DOI 10.1186/s12860-016-0095-7
Pubmed ID
Authors

Hong-Bo Zhao

Abstract

Pannexin (Panx) is a gene family encoding gap junction proteins in vertebrates. So far, three isoforms (Panx1, 2 and 3) have been identified. All of three Panx isoforms express in the cochlea with distinct expression patterns. Panx1 expresses in the cochlea extensively, including the spiral limbus, the organ of Corti, and the cochlear lateral wall, whereas Panx2 and Panx3 restrict to the basal cells of the stria vascularis in the lateral wall and the cochlear bony structure, respectively. However, there is no pannexin expression in auditory sensory hair cells. Recent studies demonstrated that like connexin gap junction gene, Panx1 deficiency causes hearing loss. Panx1 channels dominate ATP release in the cochlea. Deletion of Panx1 abolishes ATP release in the cochlea and reduces endocochlear potential (EP), auditory receptor current/potential, and active cochlear amplification. Panx1 deficiency in the cochlea also activates caspase-3 cell apoptotic pathway leading to cell degeneration. These new findings suggest that pannexins have a critical role in the cochlea in regard to hearing. However, detailed information about pannexin function in the cochlea and Panx mutation induced hearing loss still remain largely undetermined. Further studies are required.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 4%
Unknown 26 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 26%
Student > Bachelor 6 22%
Student > Master 5 19%
Other 2 7%
Researcher 2 7%
Other 2 7%
Unknown 3 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 26%
Medicine and Dentistry 6 22%
Agricultural and Biological Sciences 5 19%
Neuroscience 3 11%
Economics, Econometrics and Finance 1 4%
Other 2 7%
Unknown 3 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2017.
All research outputs
#8,593,148
of 11,192,687 outputs
Outputs from BMC Cell Biology
#190
of 266 outputs
Outputs of similar age
#177,163
of 277,563 outputs
Outputs of similar age from BMC Cell Biology
#3
of 11 outputs
Altmetric has tracked 11,192,687 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 266 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,563 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.