Title |
Molecular characterization of hepatitis B virus X gene in chronic hepatitis B patients
|
---|---|
Published in |
Virology Journal, July 2012
|
DOI | 10.1186/1743-422x-9-131 |
Pubmed ID | |
Authors |
Luciana Barbini, Luciana Tadey, Silvina Fernandez, Belen Bouzas, Rodolfo Campos |
Abstract |
HBV-X protein is associated with the pathogenesis of HBV related diseases, specially in hepatocellular carcinomas of chronic patients. Genetic variability of the X gene includes genotypic specific variations and mutations emerging during chronic infection. Its coding sequence overlaps important regions for virus replication, including the basal core promoter. Differences in the X gene may have implications in biological functions of the protein and thus, affect the evolution of the disease. There are controversial results about the consequences of mutations in this region and their relationship with pathogenesis. The purpose of this work was to describe the diversity of HBV-X gene in chronic hepatitis patients infected with different genotypes, according to liver disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Argentina | 1 | 2% |
Unknown | 46 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 26% |
Student > Master | 6 | 13% |
Student > Doctoral Student | 6 | 13% |
Student > Ph. D. Student | 3 | 6% |
Student > Bachelor | 2 | 4% |
Other | 9 | 19% |
Unknown | 9 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 17 | 36% |
Medicine and Dentistry | 11 | 23% |
Biochemistry, Genetics and Molecular Biology | 7 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Environmental Science | 1 | 2% |
Other | 0 | 0% |
Unknown | 10 | 21% |