Title |
The Majority of Dorsal Spinal Cord Gastrin Releasing Peptide is Synthesized Locally Whereas Neuromedin B is Highly Expressed in Pain- and Itch-Sensing Somatosensory Neurons
|
---|---|
Published in |
Molecular Pain, January 2012
|
DOI | 10.1186/1744-8069-8-52 |
Pubmed ID | |
Authors |
Michael S Fleming, Daniel Ramos, Seung Baek Han, Jianyuan Zhao, Young-Jin Son, Wenqin Luo |
Abstract |
Itch is one of the major somatosensory modalities. Some recent findings have proposed that gastrin releasing peptide (Grp) is expressed in a subset of dorsal root ganglion (DRG) neurons and functions as a selective neurotransmitter for transferring itch information to spinal cord interneurons. However, expression data from public databases and earlier literatures indicate that Grp mRNA is only detected in dorsal spinal cord (dSC) whereas its family member neuromedin B (Nmb) is highly expressed in DRG neurons. These contradictory results argue that a thorough characterization of the expression of Grp and Nmb is warranted. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 53 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 30% |
Student > Master | 9 | 17% |
Researcher | 8 | 15% |
Student > Bachelor | 6 | 11% |
Professor | 4 | 8% |
Other | 6 | 11% |
Unknown | 4 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 15 | 28% |
Agricultural and Biological Sciences | 12 | 23% |
Medicine and Dentistry | 9 | 17% |
Biochemistry, Genetics and Molecular Biology | 4 | 8% |
Business, Management and Accounting | 3 | 6% |
Other | 5 | 9% |
Unknown | 5 | 9% |