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The identification of informative genes from multiple datasets with increasing complexity

Overview of attention for article published in BMC Bioinformatics, January 2010
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Title
The identification of informative genes from multiple datasets with increasing complexity
Published in
BMC Bioinformatics, January 2010
DOI 10.1186/1471-2105-11-32
Pubmed ID
Authors

S Yahya Anvar, Peter AC 't Hoen, Allan Tucker

Abstract

In microarray data analysis, factors such as data quality, biological variation, and the increasingly multi-layered nature of more complex biological systems complicates the modelling of regulatory networks that can represent and capture the interactions among genes. We believe that the use of multiple datasets derived from related biological systems leads to more robust models. Therefore, we developed a novel framework for modelling regulatory networks that involves training and evaluation on independent datasets. Our approach includes the following steps: (1) ordering the datasets based on their level of noise and informativeness; (2) selection of a Bayesian classifier with an appropriate level of complexity by evaluation of predictive performance on independent data sets; (3) comparing the different gene selections and the influence of increasing the model complexity; (4) functional analysis of the informative genes.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 10%
Spain 3 7%
Germany 1 2%
Hong Kong 1 2%
Turkey 1 2%
Italy 1 2%
Canada 1 2%
Unknown 29 71%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 34%
Student > Ph. D. Student 8 20%
Other 5 12%
Student > Bachelor 3 7%
Professor > Associate Professor 3 7%
Other 6 15%
Unknown 2 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 39%
Computer Science 9 22%
Biochemistry, Genetics and Molecular Biology 7 17%
Medicine and Dentistry 4 10%
Mathematics 1 2%
Other 2 5%
Unknown 2 5%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 July 2012.
All research outputs
#20,161,674
of 22,671,366 outputs
Outputs from BMC Bioinformatics
#6,820
of 7,247 outputs
Outputs of similar age
#171,385
of 179,091 outputs
Outputs of similar age from BMC Bioinformatics
#53
of 59 outputs
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