Title |
Longitudinal MRI contrast enhanced monitoring of early tumour development with manganese chloride (MnCl2) and superparamagnetic iron oxide nanoparticles (SPIOs) in a CT1258 based in vivo model of prostate cancer
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Published in |
BMC Cancer, July 2012
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DOI | 10.1186/1471-2407-12-284 |
Pubmed ID | |
Authors |
Katharina A Sterenczak, Martin Meier, Silke Glage, Matthias Meyer, Saskia Willenbrock, Patrick Wefstaedt, Martina Dorsch, Jörn Bullerdiek, Hugo Murua Escobar, Hans Hedrich, Ingo Nolte |
Abstract |
Cell lines represent a key tool in cancer research allowing the generation of neoplasias which resemble initial tumours in in-vivo animal models. The characterisation of early tumour development is of major interest in order to evaluate the efficacy of therapeutic agents. Magnetic resonance imaging (MRI) based in-vivo characterisation allows visualisation and characterisation of tumour development in early stages prior to manual palpation. Contrast agents for MRI such as superparamagnetic iron oxide nanoparticles (SPIOs) and manganese chloride (MnCl2) represent powerful tools for the in-vivo characterisation of early stage tumours. In this experimental study, we labelled prostate cancer cells with MnCl2 or SPIOs in vitro and used 1 T MRI for tracing labelled cells in-vitro and 7 T MRI for tracking in an in-vivo animal model. |
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