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Effect of deoxyribonuclease I treatment for dementia in end-stage Alzheimer’s disease: a case report

Overview of attention for article published in Journal of Medical Case Reports, May 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#1 of 2,500)
  • High Attention Score compared to outputs of the same age (99th percentile)

Mentioned by

news
66 news outlets
twitter
4 tweeters
patent
1 patent
facebook
1 Facebook page
reddit
1 Redditor

Citations

dimensions_citation
14 Dimensions

Readers on

mendeley
39 Mendeley
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Title
Effect of deoxyribonuclease I treatment for dementia in end-stage Alzheimer’s disease: a case report
Published in
Journal of Medical Case Reports, May 2016
DOI 10.1186/s13256-016-0931-6
Pubmed ID
Authors

Victor Tetz, George Tetz

Abstract

Alzheimer's disease is the most common cause of dementia and is characterized by a progressive loss of brain tissue leading to amyloid-β accumulation and severe decline in cognitive function. The cause of Alzheimer's disease is poorly understood, and available treatments are limited in their efficacy, particularly for patients with more severe symptoms. We report the case of a 77-year-old Caucasian man with severe dementia and behavioral disturbance secondary to Alzheimer's disease treated with memantine who began adjunct treatment with deoxyribonuclease I. Prior to initiation of deoxyribonuclease I treatment, our patient appeared to be in a stuporous state, with a Mini-Mental State Examination score of 3 and a Functional Assessment Staging Test score of 7. After obtaining informed consent from family members, we started administration of 120 mg of deoxyribonuclease I per day (1500 KU/mg) for treatment of severe cognitive impairment. Our patient began to demonstrate rapid, considerable improvement in cognitive function 2 days following initiation of deoxyribonuclease I treatment. After 2 months of continued treatment, Mini-Mental State Examination and Functional Assessment Staging Test scores were 18 and 4, respectively.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 38 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 26%
Other 5 13%
Researcher 5 13%
Student > Master 4 10%
Student > Ph. D. Student 3 8%
Other 5 13%
Unknown 7 18%
Readers by discipline Count As %
Nursing and Health Professions 7 18%
Medicine and Dentistry 5 13%
Psychology 5 13%
Agricultural and Biological Sciences 4 10%
Immunology and Microbiology 2 5%
Other 6 15%
Unknown 10 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 517. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2018.
All research outputs
#18,805
of 14,834,764 outputs
Outputs from Journal of Medical Case Reports
#1
of 2,500 outputs
Outputs of similar age
#797
of 265,966 outputs
Outputs of similar age from Journal of Medical Case Reports
#1
of 1 outputs
Altmetric has tracked 14,834,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,500 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,966 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them