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Calcium activated adenylyl cyclase AC8 but not AC1 is required for prolonged behavioral anxiety

Overview of attention for article published in Molecular Brain, May 2016
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Title
Calcium activated adenylyl cyclase AC8 but not AC1 is required for prolonged behavioral anxiety
Published in
Molecular Brain, May 2016
DOI 10.1186/s13041-016-0239-x
Pubmed ID
Authors

Matteo Bernabucci, Min Zhuo

Abstract

Anxiety disorder is a state of mental discomfort while acute anxiety induces an enhancement of vigilance/arousal or increased anxious responses. Most of the previous studies investigated basic mechanisms for acute anxiety, while less information is available for prolonged or repetitive anxiety. In the present study, we wanted to examine possible molecular mechanisms for behavioral anxiety after repeated exposures. Performing a paradigm of five sessions of the elevated plus-maze (EPM), we show that the repeated exposure to the EPM induces a long-lasting anxiety causing a gradual increase of anxiolytic activity, which is maintained for at least 21 days. Genetic deletion of AC8 (adenylyl cyclase 8) but not AC1 abolished long-lasting anxiety. Our results suggest that calcium-stimulated AC8 is required to sustain the long-lasting anxiety caused by repeated EPM testing, and we can identify in AC8 a novel target for treating anxiety-related mood disorders.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 31%
Student > Bachelor 3 19%
Researcher 2 13%
Student > Master 1 6%
Professor 1 6%
Other 0 0%
Unknown 4 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 19%
Agricultural and Biological Sciences 3 19%
Pharmacology, Toxicology and Pharmaceutical Science 2 13%
Medicine and Dentistry 2 13%
Computer Science 1 6%
Other 1 6%
Unknown 4 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 May 2016.
All research outputs
#5,939,826
of 7,831,397 outputs
Outputs from Molecular Brain
#328
of 420 outputs
Outputs of similar age
#187,994
of 269,126 outputs
Outputs of similar age from Molecular Brain
#25
of 30 outputs
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So far Altmetric has tracked 420 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
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We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.