Title |
Comparative genomics of Shiga toxin encoding bacteriophages
|
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Published in |
BMC Genomics, July 2012
|
DOI | 10.1186/1471-2164-13-311 |
Pubmed ID | |
Authors |
Darren L Smith, David J Rooks, Paul CM Fogg, Alistair C Darby, Nick R Thomson, Alan J McCarthy, Heather E Allison |
Abstract |
Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause severe, life-threatening disease and Stx toxin is an integral virulence factor. The Stx-bacteriophage vB_EcoP-24B, commonly referred to as Ф24B, is capable of multiply infecting a single bacterial host cell at a high frequency, with secondary infection increasing the rate at which subsequent bacteriophage infections can occur. This is biologically unusual, therefore determining the genomic content and context of Ф24B compared to other lambdoid Stx phages is important to understanding the factors controlling this phenomenon and determining whether they occur in other Stx phages. |
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