Title |
Chimeric Hepatitis B core antigen virus-like particles displaying the envelope domain III of dengue virus type 2
|
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Published in |
Journal of Nanobiotechnology, July 2012
|
DOI | 10.1186/1477-3155-10-30 |
Pubmed ID | |
Authors |
Upasana Arora, Poornima Tyagi, Sathyamangalam Swaminathan, Navin Khanna |
Abstract |
Dengue is a global public health problem for which no drug or vaccine is available. Currently, there is increasing interest in developing non-replicating dengue vaccines based on a discrete antigenic domain of the major structural protein of dengue viruses (DENVs), known as envelope domain III (EDIII). The use of bio-nanoparticles consisting of recombinant viral structural polypeptides, better known as virus-like particles (VLPs), has emerged as a potential platform technology for vaccine development. This work explores the feasibility of developing nanoparticles based on E. coli-expressed recombinant Hepatitis B virus core antigen (HBcAg) designed to display EDIII moiety of DENV on the surface. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 1 | 1% |
French Polynesia | 1 | 1% |
Switzerland | 1 | 1% |
Unknown | 91 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 22 | 23% |
Researcher | 16 | 17% |
Student > Master | 15 | 16% |
Student > Bachelor | 9 | 10% |
Student > Doctoral Student | 6 | 6% |
Other | 13 | 14% |
Unknown | 13 | 14% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 37 | 39% |
Biochemistry, Genetics and Molecular Biology | 12 | 13% |
Medicine and Dentistry | 12 | 13% |
Immunology and Microbiology | 7 | 7% |
Computer Science | 2 | 2% |
Other | 13 | 14% |
Unknown | 11 | 12% |