Title |
Integrative structural modeling with small angle X-ray scattering profiles
|
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Published in |
BMC Molecular and Cell Biology, July 2012
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DOI | 10.1186/1472-6807-12-17 |
Pubmed ID | |
Authors |
Dina Schneidman-Duhovny, Seung Joong Kim, Andrej Sali |
Abstract |
Recent technological advances enabled high-throughput collection of Small Angle X-ray Scattering (SAXS) profiles of biological macromolecules. Thus, computational methods for integrating SAXS profiles into structural modeling are needed more than ever. Here, we review specifically the use of SAXS profiles for the structural modeling of proteins, nucleic acids, and their complexes. First, the approaches for computing theoretical SAXS profiles from structures are presented. Second, computational methods for predicting protein structures, dynamics of proteins in solution, and assembly structures are covered. Third, we discuss the use of SAXS profiles in integrative structure modeling approaches that depend simultaneously on several data types. |
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France | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
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Scientists | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
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United States | 3 | 2% |
United Kingdom | 2 | 1% |
France | 1 | <1% |
Korea, Republic of | 1 | <1% |
Turkey | 1 | <1% |
Australia | 1 | <1% |
Germany | 1 | <1% |
Denmark | 1 | <1% |
Italy | 1 | <1% |
Other | 0 | 0% |
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Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 52 | 30% |
Researcher | 40 | 23% |
Student > Master | 21 | 12% |
Professor | 12 | 7% |
Professor > Associate Professor | 11 | 6% |
Other | 25 | 14% |
Unknown | 12 | 7% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 27 | 16% |
Chemistry | 27 | 16% |
Physics and Astronomy | 15 | 9% |
Engineering | 4 | 2% |
Other | 15 | 9% |
Unknown | 25 | 14% |